Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries.
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چکیده
منابع مشابه
Basic fibroblast growth factor stimulates corneal endothelial cell growth and endothelial wound healing of human corneas.
PURPOSE To determine the dose response of human recombinant basic fibroblast growth factor (bFGF) on mitogenic activity, and the supplementary role of serum in cultured bovine and human corneal endothelial cells (BCECs, HCECs). To investigate the effect of bFGF on endothelial wound healing of human corneas in vitro. METHODS In cell culture, DNA synthesis was assessed by 3H-thymidine incorpora...
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Neuronal cells from cerebral hemispheres of 13-day-old rat embryos were grown in a serum-free culture medium for 48 h, 4 or 8 days. The neuronal precursor cells proliferate for 5 days. The addition of bovine brain basic fibroblast growth factor stimulates their proliferation as determined by measurement of [125I]-iododeoxyuridine incorporation and by autoradiographic analysis after [3H]thymidin...
متن کاملBasic, not acidic fibroblast growth factor stimulates proliferation of cultured human retinal pigment epithelial cells.
PURPOSE In this study, we evaluated a possible effect of acidic and basic fibroblast growth factor (aFGF, bFGF) on the proliferation of human retinal pigment epithelial (RPE) cells in culture. As the RPE is the primary source for bFGF in the retina, such an effect would suggest autocrinic actions of FGFs. METHODS Primary cultures of human and porcine RPE and an established human RPE cell line...
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Endothelial cell (EC) migration is a regulatory event in the formation and repair of blood vessels. Although serum contains substantial promigratory activity, the responsible components and especially the role of lipoproteins have not been determined. We examined the effect of plasma high-density lipoprotein (HDL) on the movement of ECs in vitro. Confluent cultures of bovine aortic ECs in serum...
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Objectives—Inward rectifier K currents (Kir) determine the resting membrane potential and thereby modulate essential Ca -dependent pathways, like cell growth and synthesis of vasoactive agents in endothelial cells. Basic fibroblast growth factor (bFGF) acts as a vasodilatator and angiogenic factor. Therefore, we investigated the effect of bFGF on Kir and assessed the role in proliferation and n...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1990
ISSN: 0021-9738
DOI: 10.1172/jci114665